翻訳と辞書 Words near each other ・ Photographer (disambiguation) ・ Photographer (film) ・ Photographer of Dreams ・ Photographers of the African-American Civil Rights Movement ・ Photographers of the American Civil War ・ Photo-story ・ Photoablation ・ Photoacoustic Doppler effect ・ Photoacoustic effect ・ Photoacoustic imaging ・ Photoacoustic spectroscopy ・ Photoacoustic tomography ・ Photoactivatable fluorescent protein ・ Photoactivatable probes ・ Photoactivated localization microscopy ・ Photoactivated peptide ・ Photoactive layer ・ Photoaffinity labeling ・ Photoaging ・ Photoalbum (album) ・ Photoanalysis ・ Photoanimation ・ Photoassimilate ・ Photobacterium ・ Photobacterium damselae subsp. piscicida ・ Photobacterium leiognathi ・ Photobacterium phosphoreum ・ Photobacterium profundum ・ Photobatik ・ Photobiography Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Photoactivated peptide ： ウィキペディア英語版 Photoactivated peptide Photoactivated peptides are modified natural or synthetic peptides the functions of which can be activated with light. This can be done either irreversibly or in a reversible way. Caged peptides which contain photocleavable protecting groups belong to irreversibly activated peptides. Reversible activation/deactivation of peptide function are achieved by incorporation photo-controllable fragments (molecular photoswitches) in the side chains or in the backbone of peptide templates to get the photo-controlled peptides, which can reversibly change their structure upon irradiation with light of different wavelength. As the consequence, the properties, function and biological activity of the modified peptides can be controlled by light. Since light can be directed to specific areas, such peptides can be activated only at targeted sites. Azobenzenes, and diarylethenes can be used as the photoswitches. For therapeutic use, photoswitches with longer wavelengths (near-infrared, to penetrate tissue) or the use of two-photon excitation are required, coupled with improved methods for peptide delivery to live cells. ==Applications== Photoactivated peptides are potentially useful for cancer therapy, other light-controlled drugs and in tools to probe molecular interactions in intact cells and whole organisms.〔 The initial peptides were successfully used to kill B-cell lymphoma cancer cells. The reference synthetic short peptide was alkylated with azobenzene crosslinkers and used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, which were the initial events of the intrinsic apoptosis pathway.〔 Gramicidin S analogues containing a diarylethene fragment〔 display clear-cut reversible change of antimicrobial activity. In an inactive, UV-inducible photo-form they are harmless to bacteria cells, but are bactericidal after the activation with visible (amber) light. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Photoactivated peptide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.